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When employing PERCOCET with CYP3A4 inducers or discontinuing CYP3A4 inhibitors, monitor clients closely at Recurrent intervals and consider escalating the opioid dosage if desired to keep up enough analgesia or if symptoms of opioid withdrawal take place [see Safeguards; Drug Interactions].Fetal/Neonatal Adverse Reactions Usage of opioid analgesic